HJ445A | Myoferlin inhibitor | Probechem Biochemicals

Chemical Structure : HJ445A

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HJ445A (HJ 445A)

货号: PC-21516Not For Human Use, Lab Use Only.

HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM.

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生物&药学活性

HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM.
HJ445A potently inhibits the proliferation of gastric cancer cells with IC50 values of 0.16 and 0.14 μM in MGC803 and MKN45, respectively.
HJ445A prevents the migration of gastric cancer cells by reversing the epithelial–mesenchymal transition (EMT) process and inhibits the colony formation of the MKN45 cells in a concentration-dependent manner.
HJ445A efficiently induces the apoptosis of gastric cancer cells with apoptosis rates at 0, 0.1, 0.2, 0.4, and 0.8 μM were 3.1, 3.4, 5.7, 50.2, and 54.0%, respectively.
HJ445A (15 and 30 mg/kg/day) exhibited antitumor efficacy in the gastric cancer xenograft model.

物理化学性质&存储条件

分子量	445.53
分子式	C24H27N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-2H-1,2,3-Triazolyl)butyl)-3-(3-ethyl-5-(4-methoxyphenyl)-1-1H-1,2,4-triazolyl) Benzamide

参考文献

1. Haijun Gu, et al. J Med Chem. 2023 Dec 6.

HJ445A (HJ 445A)

生物&药学活性

物理化学性质&存储条件

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HJ445A (HJ 445A)

生物&药学活性

物理化学性质&存储条件

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