HIV InSTI-1 |CAS:1549802-58-5 Probechem Biochemicals

Chemical Structure : HIV InSTI-1

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HIV InSTI-1 (HIV integrase strand transfer inhibitor 1)

货号: PC-60406Not For Human Use, Lab Use Only.

HIV InSTI-1 is a potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

HIV InSTI-1 is a potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay.
HIV InSTI-1 shows Mutant Fold Shift 1/1/1/1/2/4 for E92Q/Y143R/Q148R/Q148K/N155H/G140S-Q148H compared with WT enzyme, respectively.
HIV InSTI-1 demonstrates desired virological profile and preclinical pharmacokinetic profile.

物理化学性质&存储条件

分子量	501.939
分子式	C25H25ClFN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R,5S)-8'-(3-chloro-4-fluorobenzyl)-6'-hydroxy-2'-((S)-2-hydroxypropyl)-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione

参考文献

1. Schreier JD, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2038-2046.

HIV InSTI-1 (HIV integrase strand transfer inhibitor 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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HIV InSTI-1 (HIV integrase strand transfer inhibitor 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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