HIV-1 inhibitor 5b

Chemical Structure : HIV-1 inhibitor 5b

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货号: PC-36158Not For Human Use, Lab Use Only.

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

HIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM), also shows potency against NRTI- and NNRTI-resistant HIV-1 (EC50=1-3 nM); shows a chemical backbone similar to the clinically used integrase (IN) strand transfer inhibitor (INSTI) elvitegravir, but has no detectable INSTI activity; various drug-resistant HIV-1 strains did not display cross resistance to HIV-1 inhibitor 5b; remains its anti-HIV-1 activity even after the viral integration stage, significantly suppresses p24 antigen production in HIV-1 latently infected cells exposed with TNF-alpha; demonstrates favorable pharmacokinetic profiles in mice.

物理化学性质&存储条件

分子量	369.372
分子式	C20H17F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-amino-2,4-difluorophenyl)-7-(3,5-dimethyl-4,5-dihydroisoxazol-4-yl)quinolin-4(1H)-one

参考文献

1. Shiroishi-Wakatsuki T, et al. Antiviral Res. 2019 Feb;162:101-109.