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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-HIV-1 inhibitor 18A
HIV-1 inhibitor 18A

Chemical Structure : HIV-1 inhibitor 18A

CAS No.: 331261-50-8

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HIV-1 inhibitor 18A (Compound 18A)

货号: PC-62258Not For Human Use, Lab Use Only.

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.

物理化学性质&存储条件

分子量 313.33
分子式 C14H11N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide

参考文献

1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52.

2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29.

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