HIV-1 Integrase inhibitor GS-B | HIV-1 integrase inhibitor

Chemical Structure : HIV-1 Integrase inhibitor GS-B

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HIV-1 Integrase inhibitor GS-B (GS-B)

货号: PC-72633Not For Human Use, Lab Use Only.

HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.

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生物&药学活性

HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.
GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively.

物理化学性质&存储条件

分子量	437.511
分子式	C26H28FNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-(tert-butoxy)-2-(4-(8-fluoro-5-methylchroman-6-yl)-2-methylquinolin-3-yl)acetic acid

参考文献

1. Manuel Tsiang, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203.

2. Mini Balakrishnan, et al. PLoS One. 2013 Sep 9;8(9):e74163.

3. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321.

HIV-1 Integrase inhibitor GS-B (GS-B)

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物理化学性质&存储条件

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HIV-1 Integrase inhibitor GS-B (GS-B)

生物&药学活性

物理化学性质&存储条件

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