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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-HIF1-IN-2
HIF1-IN-2

Chemical Structure : HIF1-IN-2

CAS No.: 159915-87-4

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HIF1-IN-2

货号: PC-70269Not For Human Use, Lab Use Only.

HIF1-IN-2 is a potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HIF1-IN-2 is a potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB.
    HIF1-IN-2 robustly induces PGK1 and Enolase 1 expression, also inhibit endogenous HIF-1 targets.

    物理化学性质&存储条件

    分子量 453.583
    分子式 C26H35N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-2-(2-((4-((E)-1-(butoxyimino)propyl)-2,5-dimethylphenoxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

    参考文献

    1. Lin X, et al. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):174-9.

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