HHV protease inhibitor 43

Chemical Structure : HHV protease inhibitor 43

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货号: PC-38414Not For Human Use, Lab Use Only.

HHV protease inhibitor 43 is an irreversible small molecule inhibitor of human herpesvirus (HHV) protease targeting a non-catalytic cysteine (C161) with IC50 of 4 uM (HCMV), exhibits broad-spectrum inhibition of other HHV protease homologs.

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250 mg		Get quote

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生物&药学活性

HHV protease inhibitor 43 is an irreversible small molecule inhibitor of human herpesvirus (HHV) protease targeting a non-catalytic cysteine (C161) with IC50 of 4 uM (HCMV), exhibits broad-spectrum inhibition of other HHV protease homologs.
HHV protease inhibitor 43 demonstrates inhibitor stabilization of HCMV Pr homodimerization, exploiting a conformational equilibrium to block proteolysis.
HHV protease inhibitor 43 causes a dose-dependent decrease in HCMV replication in HFF-1 cells with IC50 of 5 uM, with no significant cytotoxicity (CC50>20 uM).

物理化学性质&存储条件

分子量	398.847
分子式	C20H19ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-(3-chloro-2-oxopropyl)-4-phenyl-1H-1,2,3-triazol-5-yl)methyl benzylcarbamate

参考文献

1. Kaitlin R Hulce, et al. Cell Chem Biol. 2022 Mar 30;S2451-9456(22)00124-6.