HG6-64-1 |CAS:1315329-43-1 Probechem Biochemicals

Chemical Structure : HG6-64-1

CAS No.: 1315329-43-1

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HG6-64-1 (HG 6-64-1)

货号: PC-42954Not For Human Use, Lab Use Only.

HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively.

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5 mg	￥880	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
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100 mg		Get quote

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生物&药学活性

HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively.
HG6-64-1 also inhibits ZAK, p38α, Src, Lyn, CSK and EPH-family kinases (IC50=50-100 nM).
HG6-64-1 inhibits GCK signaling DLBCL cell lines with EC50 of 1.83-157 nM, induces G0/G1 cell-cycle arrest and cell death.
HG6-64-1 inhibits the growth of DLBCL xenograft tumors and prolongs the survival of tumor-bearing mice.

物理化学性质&存储条件

分子量	577.6399
分子式	C32H34F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methyl-

参考文献

1. Tan L, et al. J Med Chem. 2015 Jan 8;58(1):183-96.

2. Matthews JM, et al. Blood. 2016 Jul 14;128(2):239-48.

HG6-64-1 (HG 6-64-1)

生物&药学活性

物理化学性质&存储条件

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HG6-64-1 (HG 6-64-1)

生物&药学活性

物理化学性质&存储条件

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