HG106 | SLC7A11 inhibitor | Probechem Biochemicals

Chemical Structure : HG106

CAS No.: 928712-10-1

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HG106 (HG 106)

货号: PC-73129Not For Human Use, Lab Use Only.

HG106 (HG 106) is a potent, selective SLC7A11 inhibitor, selectively kills KRAS-mutant lung adenocarcinoma (LUAD) cells.

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25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

HG106 (HG 106) is a potent, selective SLC7A11 inhibitor, selectively kills KRAS-mutant lung adenocarcinoma (LUAD) cells.
HG106 exerts substantial cytotoxic effects on KRAS-mutant H441 cells, which are strikingly reduced by addition of β-mercaptoethanol and l-cysteine.
HG106 preferentially decreases the viability of KRAS-mutant LUAD cells (A549 cells IC50=3.7 uM), dose-dependently reduces the oxygen consumption rate and disrupted MMP in A549 and H441 cells.
HG106 significantly induced apoptosis in KRAS-mutant LUAD cells and inhibited colony formation.
HG106 exhibits potent in vivo efficacy in a patient-derived xenograft (PDX) model of LUAD harboring a G12V mutation in KRAS.

物理化学性质&存储条件

分子量	316.745
分子式	C15H13ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(2-(4-methoxyphenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide

参考文献

1. Hu K, et al. J Clin Invest. 2020 Apr 1;130(4):1752-1766.

HG106 (HG 106)

生物&药学活性

物理化学性质&存储条件

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HG106 (HG 106)

生物&药学活性

物理化学性质&存储条件

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