HG-9-91-01

Chemical Structure : HG-9-91-01

CAS No.: 1456858-58-4

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货号: PC-21590Not For Human Use, Lab Use Only.

HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes.
HG-9-91-01 significantly decreases proinflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-12p40) and increased IL-10 secretion by human myeloid cells stimulated with TLR2 and-4 agonists.

物理化学性质&存储条件

分子量	567.69
分子式	C32H37N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea

参考文献

1. Sundberg TB, et al. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.

2. Patel K, et al. Nat Commun. 2014 Aug 4;5:4535.

3. Sundberg TB, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.

HG-9-91-01

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HG-9-91-01

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