HG-7-92-01 | TAK1/MAP4K2 inhibitor, c-Fes inhibitor | Probechem Biochemicals

Chemical Structure : HG-7-92-01

CAS No.: 1315355-93-1

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HG-7-92-01 (NG25)

货号: PC-61640Not For Human Use, Lab Use Only.

HG-7-92-01 (NG25) is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, also is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.

规格	价格	库存
1 mg	￥780	In stock
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HG-7-92-01 (NG25) is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, also is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
HG-7-92-01 (NG25) displays intermediate selectivity profiles (selectivity score=0.18) against 353 kinases.
NG25 also potently suppresses several kinases such as LYN, CSK, FER, p38α, ABL,ARG and SRC, with IC50s of 12.9, 56.4, 82.3, 102, 75.2, and 113 nM, respectively.
HG-7-92-01 (NG25) 400 nM) completely inhibits CpG B- or CpG A-stimulated secretion of IFNα and CL097-stimulated secretion of IFNβ.
HG-7-92-01 (NG25) reduces cell viability of breast cancer cell lines in a dose dependent manner.

物理化学性质&存储条件

分子量	537.587
分子式	C29H30F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (5.4 mg/mL)
Chemical Name/SMILES	3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide

参考文献

1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40.

2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178.

HG-7-92-01 (NG25)

生物&药学活性

物理化学性质&存储条件

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HG-7-92-01 (NG25)

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物理化学性质&存储条件

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