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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-HFI-419
HFI-419

Chemical Structure : HFI-419

CAS No.: 1110650-72-0

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HFI-419 (HFI 419)

货号: PC-21697Not For Human Use, Lab Use Only.

HFI-419 is a specifc inhibits of insulin-regulated aminopeptidase (IRAP) with Ki of 0.48 uM, potent inhibits the hydrolysis of the dipeptidic substrate L-Leucine-7-amido-4-methylcoumarin with IC50 of 0.4 uM, >1000-fold lower or no affinity for related and unrelated enzymes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HFI-419 is a specifc inhibits of insulin-regulated aminopeptidase (IRAP) with Ki of 0.48 uM, potent inhibits the hydrolysis of the dipeptidic substrate L-Leucine-7-amido-4-methylcoumarin with IC50 of 0.4 uM, >1000-fold lower or no affinity for related and unrelated enzymes.

物理化学性质&存储条件

分子量 354.36
分子式 C19H18N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 2-acetamido-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylate

参考文献

1. Anthony L Albiston, et al. FASEB J. 2008 Dec;22(12):4209-17.

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