HER2-IN-3 |CAS:2011708-45-3 Probechem Biochemicals

Chemical Structure : HER2-IN-3

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HER2-IN-3

货号: PC-62304Not For Human Use, Lab Use Only.

HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2, inhibits the active HER2/HER3 heterodimer in multiple oncogenic settings.

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生物&药学活性

HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2, inhibits the active HER2/HER3 heterodimer in multiple oncogenic settings.
HER2-IN-3 shows superior activity to lapatinib in the 2YF/3wt + NRG cells and specificity for this cell line.
HER2-IN-3 remains sensitivity to HER2 mutations L755S (2YF-L755S/3wt), Y772_A775 dup (2YF-YVMA/3wt), and G776del_insVC (2YF-VC/3wt) cells.

物理化学性质&存储条件

分子量	372.388
分子式	C20H16N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(furan-3-yl)-2-methoxyphenyl)-5-(1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930.

HER2-IN-3

生物&药学活性

物理化学性质&存储条件

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HER2-IN-3

生物&药学活性

物理化学性质&存储条件

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