HER2-IN-2 |CAS:2011708-43-1 Probechem Biochemicals

Chemical Structure : HER2-IN-2

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HER2-IN-2

货号: PC-62303Not For Human Use, Lab Use Only.

HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases.

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生物&药学活性

HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases.
HER2-IN-2 is equipotent to lapatinib against HER2 in vitro, also able to inhibit the small amount of HER3 auto-phosphorylation.
HER2-IN-2 inhibits 2YF/3TM gatekeeper mutant Ba/F3 cells lines with IC50 of 18.63 nM.

物理化学性质&存储条件

分子量	373.372
分子式	C20H15N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(furan-2-yl)-N-(5-(furan-2-yl)-2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

参考文献

1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930.

HER2-IN-2

生物&药学活性

物理化学性质&存储条件

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HER2-IN-2

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