HEC96719 | FXR agonist | Probechem Biochemicals

Chemical Structure : HEC96719

CAS No.: 2181834-03-5

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HEC96719 (HEC-96719)

货号: PC-27234Not For Human Use, Lab Use Only.

HEC96719 is a potent, selective tricyclic farnesoid X receptor (FXR) agonist with EC50 of 1.37 nM and 1.55 nM by TR-FRET and luciferase reporter assays, respectively.

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5 mg	￥4580	In stock
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生物&药学活性

HEC96719 is a potent, selective tricyclic farnesoid X receptor (FXR) agonist with EC50 of 1.37 nM and 1.55 nM by TR-FRET and luciferase reporter assays, respectively.
HEC96719 exhibits excellent potency superior to GW4064 and obeticholic acid in in vitro and in vivo assays of FXR activation.
HEC96719 also shows higher FXR selectivity and more favorable tissue distribution dominantly in liver and intestine.
HEC96719 significantly improves histologic NASH and fibrosis with lower efficacy dose than Obeticholic acid (OCA).

物理化学性质&存储条件

分子量	549.40
分子式	C29H22Cl2N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[[1]benzoxepino[3,2-b]pyridine-11(10H),1'-cyclopropane]-7-carboxylic acid, 2-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-

参考文献

1. Cao S, et al. Eur J Med Chem. 2022 Feb 15;230:114089.

HEC96719 (HEC-96719)

生物&药学活性

物理化学性质&存储条件

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HEC96719 (HEC-96719)

生物&药学活性

物理化学性质&存储条件

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