HEC72702 |CAS:1793063-59-8 Probechem Biochemicals

Chemical Structure : HEC72702

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HEC72702 (HEC-72702;HEC 72702)

货号: PC-63328Not For Human Use, Lab Use Only.

HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.

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生物&药学活性

HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.
HEC72702 displays no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at 10 uM.
HEC72702 demonstrates a good systemic exposure and high oral bioavailability and achieves a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model.

物理化学性质&存储条件

分子量	581.457
分子式	C24H26BrFN4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((R)-4-(((R)-6-(2-Bromo-4- fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)- 3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic acid

参考文献

1. Ren Q, et al. J Med Chem. 2018 Feb 8;61(3):1355-1374.

HEC72702 (HEC-72702;HEC 72702)

生物&药学活性

物理化学性质&存储条件

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HEC72702 (HEC-72702;HEC 72702)

生物&药学活性

物理化学性质&存储条件

参考文献

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