HEC116094 | IAV PB2 inhibitor | Probechem Biochemicals

Chemical Structure : HEC116094

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HEC116094 (HEC-116094)

货号: PC-27290Not For Human Use, Lab Use Only.

HEC116094 is a potent, specific inhibitor of influenza A virus polymerase PB2 subunit with IC50 of 0.337 nM.

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生物&药学活性

HEC116094 is a potent, specific inhibitor of influenza A virus polymerase PB2 subunit with IC50 of 0.337 nM.
HEC116094 demonstrates potent activity against influenza A strains (H1N1 and H3N2), with IC50 values ranging from 0.012 to 0.069 nM, surpassing VX-787 and oseltamivir.
HEC116094 does not inhibit influenza B virus, and shows low cell cytotoxicity.
HEC116094 demonstrates IC50 values of 0.121 nM against H5N1 and 0.084 nM against H7N9 on MDCK cells.
HEC116094 (1, 3, or 10 mg/kg, BID, oral) is highly efficacious and safe in mouse influenza A virus infection model.
HEC116094 is strongly synergistic with oseltamivir in vitro.

物理化学性质&存储条件

分子量	482.51
分子式	C23H20F2N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-3-((5-fluoro-2-(5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-yl)-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid

参考文献

1. Longyu Nie, et al. Emerg Microbes Infect. 2026 Dec;15(1):2695531.

HEC116094 (HEC-116094)

生物&药学活性

物理化学性质&存储条件

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HEC116094 (HEC-116094)

生物&药学活性

物理化学性质&存储条件

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