HDAC8-IN-20a |CAS:1884231-52-0 Probechem Biochemicals

Chemical Structure : HDAC8-IN-20a

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HDAC8-IN-20a

货号: PC-60133Not For Human Use, Lab Use Only.

HDAC8-IN-20a is a potent and selective HDAC8 inhibitor with IC50 of 27 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM.
HDAC8-IN-20a efficiently blocks the activation of growth receptor survival signaling and shifts the cell cycle arrest and differentiation phenotype toward effective cell death of neuroblastoma cell lines combined with crizotinib.
HDAC8-IN-20a efficiently kills neuroblastoma cell lines carrying wildtype ALK, amplified ALK and those carrying the activating ALK F1174L mutation, as well as cells carrying the activating R1275Q mutation.

物理化学性质&存储条件

分子量	273.288
分子式	C15H15NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(benzyloxy)-N-hydroxy-4-methoxybenzamide

参考文献

1. Heimburg T, et al. J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01447.

2. Shen J, et al. Cell Death Differ. 2018 Mar 7. doi: 10.1038/s41418-018-0080-0.

HDAC8-IN-20a

生物&药学活性

物理化学性质&存储条件

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HDAC8-IN-20a

生物&药学活性

物理化学性质&存储条件

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