HDAC6 inhibitor OXHA

Chemical Structure : HDAC6 inhibitor OXHA

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货号: PC-23423Not For Human Use, Lab Use Only.

OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8.
OXHA demonstrate stronger inhibitory activity on HDAC6 than SAHA, significantly promoting α-tubulin acetylation while exerting a comparatively weaker influence on H3 acetylation.
OXHA has potent anti-proliferative activity, comparable to or slightly exceeding that of SAHA.
OXHA effectively inhibits the migratory ability of tumor cells post-irradiation.
OXHA combined IR treatment enhances micronucleus formation in tumor cells, inhibits clone formation ability of tumor cells.

物理化学性质&存储条件

分子量	450.50
分子式	C24H26N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenyl)-5-phenyloxazole-2-carboxamide

参考文献

1. Hu H, et al. Mol Biol Rep. 2024 Nov 13;51(1):1151.