HDAC6 inhibitor DR-3

Chemical Structure : HDAC6 inhibitor DR-3

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货号: PC-24228Not For Human Use, Lab Use Only.

HDAC6 inhibitor DR-3 is a selective small molecule HDAC6 inhibitor with IC50 of 78.1 nM, shows 100-fold selectivity over HDAC1.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HDAC6 inhibitor DR-3 is a selective small molecule HDAC6 inhibitor with IC50 of 78.1 nM, shows 100-fold selectivity over HDAC1.
DR-3 is effective for relieving HDAC6-mediated deacetylation of α-tubulin and exerts anti-fibrogenic effects at the transcript level in the human LX-2 hepatic myofibroblast line.
DR-3 (100 nM) suppresses hepatic stellate cell (HSC) expression of TGF-β1 mRNA in primary rat HSC, suppresses TGFβ1 induced profibrogenic SMAD signaling.
DR-3 shows antifibrogenic activities in human precision-cut liver slice cultures, prevents fibrosis progression in the diseased human liver.

物理化学性质&存储条件

分子量	236.27
分子式	C12H16N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-4-(morpholinomethyl)benzamide

参考文献

1. Borrello MT, et al. FEBS J. 2025 Mar 14. doi: 10.1111/febs.70062.