HDAC6 inhibitor Compound 7b

Chemical Structure : HDAC6 inhibitor Compound 7b

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货号: PC-27052Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HDAC6 inhibitor Compound 7b is a potent, selective HDAC6 inhibitor, inhibits proliferation, colony and spheroid formation as well as viability of prostate cancer cells, kills prostate cancer cells via HSP90α hyperacetylation-mediated androgen receptor protein downregulation.
HDAC6 inhibitor Compound 7b induces BCR-ABL ubiquitination and degradation.
Imatinib-7b combination causes a synergistic anticancer effect in vitro and in vivo.
Imatinib-7b combination reduces the CML CSC population.

物理化学性质&存储条件

分子量	432.47
分子式	C23H28O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	heptane-1,7-diyl bis(4-hydroxy-3-methoxybenzoate)

参考文献

1. Carole Seidel, et al. Biochem Pharmacol. 2016 Jan 1:99:31-52.