HDAC6 inhibitor 4d | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : HDAC6 inhibitor 4d

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HDAC6 inhibitor 4d (Nexturastat B)

货号: PC-27054Not For Human Use, Lab Use Only.

HDAC6 inhibitor 4d (Nexturastat B) is a potent, isoform-selective HDAC6 inhibitor with IC50 of 1.6 nM, shows >500-fold selectivity over HDAC1.

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生物&药学活性

HDAC6 inhibitor 4d (Nexturastat B) is a potent, isoform-selective HDAC6 inhibitor with IC50 of 1.6 nM, shows >500-fold selectivity over HDAC1.
HDAC6 inhibitor 4d exhibits antiproliferative effects on several types of melanoma and lymphoma cells.
HDAC6 inhibitor 4d selectively increases acetylated tubulin levels in vitro and elicits an immune response through down-regulating cytokine IL-10.
HDAC6 inhibitor 4d possesses improved capability to inhibit melanoma tumor growth in vivo.

物理化学性质&存储条件

分子量	381.44
分子式	C20H23N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[1-Butyl-3-(1H-indazol-6-yl)ureido]methyl]-N-hydroxybenzamide

参考文献

1. Tavares MT, et al. ACS Med Chem Lett. 2017 Sep 5;8(10):1031-1036.

HDAC6 inhibitor 4d (Nexturastat B)

生物&药学活性

物理化学性质&存储条件

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HDAC6 inhibitor 4d (Nexturastat B)

生物&药学活性

物理化学性质&存储条件

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