HDAC6-AR-IN-10 |CAS:2042519-10-6 Probechem Biochemicals

Chemical Structure : HDAC6-AR-IN-10

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HDAC6-AR-IN-10

货号: PC-62788Not For Human Use, Lab Use Only.

HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM).
HDAC6-AR-IN-10 inhibits AR signaling and reduces the AR protein levels in LNCaP cells.
HDAC6-AR-IN-10 is a useful tool compound in pharmacology studies to evaluate the value of dual inhibition of AR and HDAC6.

物理化学性质&存储条件

分子量	579.571
分子式	C26H25F4N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-(6-(hydroxyamino)-6-oxohexyl)benzamide

参考文献

1. Jadhavar PS, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228.

HDAC6-AR-IN-10

生物&药学活性

物理化学性质&存储条件

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HDAC6-AR-IN-10

生物&药学活性

物理化学性质&存储条件

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