HDAC3 inhibitor LSQ-28

Chemical Structure : HDAC3 inhibitor LSQ-28

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货号: PC-23965Not For Human Use, Lab Use Only.

LSQ-28 is a potent, selective HDAC3 inhibitor with IC50 of 42 nM, >150-fold selective over HDAC1, HDAC2, and HDAC6.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

LSQ-28 is a potent, selective HDAC3 inhibitor with IC50 of 42 nM, >150-fold selective over HDAC1, HDAC2, and HDAC6.
LSQ-28 does not inhibit HDAC4, 5, 7–10 at concentrations up to 10 μM, but inhibits HDAC11 with an IC50 value of 8.87 μM.
LSQ-28 exhibits antiproliferative activities across HCT-116 (colorectal carcinoma), 4T1 (breast cancer), B16-F10 (melanoma), and SK-OV-3 (ovarian cancer) with IC50 of 5.558 to 12.49 μM.
LSQ-28 inhibits B16-F10 cell migration, markedly reduces the invasive capacity, possesses apoptotic potential.
LSQ-28 (5, 10, and 20 μM) induced a significant increase in Ac-H3 levels in B16-F10 and 4T1 cells.
LSQ-28 induces a dose-dependent degradation in PD-L1 levels in B16-F10 cells.
LSQ-28 enhancse the antitumor activity of PARP inhibitors through a synergistic enhancement of the DNA-damage response.
Combination treatment of LSQ-28 and olaparib significantly enhanced TGI, achieving a TGI of 91% in in 4T1 tumor xenograft models.

物理化学性质&存储条件

分子量	485.59
分子式	C31H27N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-Propyl-4-((6-(pyridin-2-yl)-11H-indolo[3,2-c]quinolin-11-yl)methyl)benzohydrazide

参考文献

1. Li S, et al. J Med Chem. 2025 Jan 28. doi: 10.1021/acs.jmedchem.4c02445.