HDAC1/2-IN-2 |CAS:937727-03-2 Probechem Biochemicals

Chemical Structure : HDAC1/2-IN-2

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HDAC1/2-IN-2

货号: PC-61915Not For Human Use, Lab Use Only.

HDAC1/2-IN-2 is a potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively.

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生物&药学活性

HDAC1/2-IN-2 is a potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively.
HDAC1/2-IN-2 displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7.
HDAC1/2-IN-2 increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM.
HDAC1/2-IN-2 exhibits tumor growth inhibition in HCT116 xenograft mice.

物理化学性质&存储条件

分子量	449.529
分子式	C23H23N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide

参考文献

1. Hamblett CL, et al. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9.

2. Methot JL, et al. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5.

HDAC1/2-IN-2

生物&药学活性

物理化学性质&存储条件

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HDAC1/2-IN-2

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