HDAC11 inhibitor B6

Chemical Structure : HDAC11 inhibitor B6

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货号: PC-24022Not For Human Use, Lab Use Only.

HDAC11 inhibitor B6 is a potent, highly selective HDAC11 inhibitor with IC50 of 51.1 nM, >90-fold selective over HDAC8 and shows no activity against all other HDAC subtypes.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HDAC11 inhibitor B6 is a potent, highly selective HDAC11 inhibitor with IC50 of 51.1 nM, >90-fold selective over HDAC8 and shows no activity against all other HDAC subtypes.
B6 induces a markedly increase in the myristoylation of SHMT2, a specific substrate of HDAC11, in HEK293T cells, with no effect on the acetylation levels of histones H3 and H4 (substrates of class I HDACs: HDAC1/2/3/8) or tubulin (a substrate of HDAC6).
B6 can be used for in vivo studies of liver diseases.
B6 mitigates FFA-induced lipid accumulation by inhibiting DNL and promoting fatty acid oxidation in AML12 cells.
B6 regulates genes involved in DNL and fatty acid oxidation through the inhibition of HDAC11.
B6 (5-10 mg/kg, 0.5% HPMC) significantly mitigates high fat diet (HFD)-induced MASLD.
B6 facilitates the phosphorylation of AMP-activated protein kinase α1 (AMPKα1) at Thr172, which consequently reduces DNL and enhances fatty acid oxidation.

物理化学性质&存储条件

分子量	425.57
分子式	C25H35N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-(5-(pentyloxy)pentyl)hydrazine-1-carbonyl)benzyl)benzamide

参考文献

1. Zhang F, et al. Adv Sci (Weinh). 2025 Feb 20:e2412903.