HCH6-1 | FPR1 inhibitor | Probechem Biochemicals

Chemical Structure : HCH6-1

CAS No.: 1435265-06-7

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HCH6-1 (FPR1 antagonist)

货号: PC-20392Not For Human Use, Lab Use Only.

HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.
HCH6-1 inhibits superoxide anion generation, elastase release, and chemotaxis in human neutrophils specifically activated by fMLF.
HCH6-1 significantly inhibits elastase release in fMLF-activated neutrophils with IC50 of 0.57 uM.
HCH6-1 reduces inflammatory cell infiltration and distortion of pulmonary architecture in the presence of LPS. HCH6-1 posttreatment shows inhibitory effects on neutrophil accumulation and lung damage in LPS-induced ALI mice

物理化学性质&存储条件

分子量	469.54
分子式	C28H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl benzoyl-L-tryptophyl-D-phenylalaninate

参考文献

1. Hung-Li Wang, et al. Biochem Pharmacol. 2023 Mar 29;115524.

HCH6-1 (FPR1 antagonist)

生物&药学活性

物理化学性质&存储条件

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HCH6-1 (FPR1 antagonist)

生物&药学活性

物理化学性质&存储条件

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