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首页-小分子抑制剂&激动剂-GPCR-GPR109A (Niacin Receptor 1)-HCAR3 agonist 5c
HCAR3 agonist 5c

Chemical Structure : HCAR3 agonist 5c

CAS No.: 68740-31-8

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HCAR3 agonist 5c (GPR109b agonist 5c)

货号: PC-23376Not For Human Use, Lab Use Only.

HCAR3 agonist 5c (GPR109b agonist 5c) is a highly subtype-specific agonist of hydroxycarboxylic acid receptor 3 (HCAR3, GPR109B) with pEC50 of 7.53 and SPR KD of 47 nM, shows no activity against GPR109a.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HCAR3 agonist 5c (GPR109b agonist 5c) is a highly subtype-specific agonist of hydroxycarboxylic acid receptor 3 (HCAR3, GPR109B) with pEC50 of 7.53 and SPR KD of 47 nM, shows no activity against GPR109a.

物理化学性质&存储条件

分子量 224.22
分子式 C10H12N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(n-propyl)amino-3-nitrobenzoic acid

参考文献

1. Skinner, P.J. et al. Bioorg. Med. Chem. Lett. 2007; 17:6619-6622

2. Ye F, et al. Cell Rep. 2024 Oct 19;43(11):114895.

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