HC-067047 |CAS:883031-03-6 Probechem Biochemicals

Chemical Structure : HC-067047

CAS No.: 883031-03-6

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HC-067047 (HC067047;HC 067047)

货号: PC-42084Not For Human Use, Lab Use Only.

HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.
HC067047 displays high selectivity against a variety of ion-channel targets, including representative channels of the TRPV, TRPC, TRPA, and TRPMs.
HC067047 inhibits endogenous TRPV4-mediated response to 4α-PDH with IC50 of 22 nM.
HC067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis without effects on bladder function.

物理化学性质&存储条件

分子量	471.5146
分子式	C26H28F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-

参考文献

1. Everaerts W, et al. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.

2. Jin M, et al. Cell Calcium. 2012 Feb;51(2):131-9.

3. Shahidullah M, et al. Am J Physiol Cell Physiol. 2012 Jun 15;302(12):C1751-61.

HC-067047 (HC067047;HC 067047)

生物&药学活性

物理化学性质&存储条件

参考文献

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HC-067047 (HC067047;HC 067047)

生物&药学活性

物理化学性质&存储条件

参考文献

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