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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-HBX41108
HBX41108

Chemical Structure : HBX41108

CAS No.: 924296-39-9

HBX41108 (HBX 41108)

货号: PC-20202Not For Human Use, Lab Use Only.

HBX41108 is a specific small-molecule inhibitor of USP7/HAUSP ubiquitin protease with IC50 of 424 nM for inhibition of Ub-AMC hydrolysis by USP7.

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10 mg ¥1980 In stock
25 mg ¥3480 In stock
50 mg ¥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HBX41108 is a specific small-molecule inhibitor of USP7/HAUSP ubiquitin protease with IC50 of 424 nM for inhibition of Ub-AMC hydrolysis by USP7.
HBX41108 shows little to no activity against a panel of serine, aspartic, and metalloproteases, calpain-1 (IC50 > 10 μmol/L), and cathepsins B, L, and S (IC50 > 1 μmol/L).
HBX 41108 inhibits USP7-mediated p53 deubiquitination (IC50=0.8 uM), increases p53 levels in a nongenotoxic manner.
HBX41108 (0.1-3 uM) inhibits HCT116 cancer cell growth and induces apoptotic cell death, induces apoptosis in a p53-dependent manner.

物理化学性质&存储条件

分子量 266.64
分子式 C13H3ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

参考文献

1. Colland F, et al. Mol Cancer Ther. 2009 Aug;8(8):2286-95.

2. Lee KW, et al. J Biol Chem. 2013 Nov 15;288(46):32886-96.

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