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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-HBX 28258
HBX 28258

Chemical Structure : HBX 28258

CAS No.: 1426544-54-8

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HBX 28258 (HBX28258)

货号: PC-62449Not For Human Use, Lab Use Only.

HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM.
    HBX 28258 exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
    HBX 28258 reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.

    物理化学性质&存储条件

    分子量 435.996
    分子式 C26H30ClN3O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Acridinecarboxamide, 9-chloro-N-[3-[ethyl(phenylmethyl)amino]propyl]-5,6,7,8-tetrahydro-

    参考文献

    1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

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