HBV RNaseH inhibitor 1466 | HBV RNaseH inhibitor | Probechem Biochemicals

Chemical Structure : HBV RNaseH inhibitor 1466

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HBV RNaseH inhibitor 1466 (CAM-I 1466)

货号: PC-23940Not For Human Use, Lab Use Only.

HBV RNaseH inhibitor 1466 is a small molecule inhibitor of HBV RNaseH, inhibits HBV replication with EC50 of 0.25 uM, decreases capsid and core protein accumulation in HepDES19 and HepG2.2.15 cells.

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生物&药学活性

HBV RNaseH inhibitor 1466 is a small molecule inhibitor of HBV RNaseH, inhibits HBV replication with EC50 of 0.25 uM, decreases capsid and core protein accumulation in HepDES19 and HepG2.2.15 cells.
1466 does not affect pregenomic RNA encapsidation, demonstrating a specific effect on empty capsids.
1466 also decreased capsid and core protein accumulation in cells transfected with a core protein expression plasmid, indicating that other HBV products are unneeded.
HBV RNaseH inhibitor 1466 is a new class of capsid assembly modulators (CAM) that inhibits capsid assembly, targeting the RNaseH and capsid assembly.

物理化学性质&存储条件

分子量	322.75
分子式	C15H15ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-(1-(((4-chlorobenzyl)oxy)imino)ethyl)-1,6-dihydroxy-4-methylpyridin-2(1H)-one

参考文献

1. Bradley DP, et al. PLoS Pathog. 2025 Feb 10;21(2):e1012920.

HBV RNaseH inhibitor 1466 (CAM-I 1466)

生物&药学活性

物理化学性质&存储条件

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HBV RNaseH inhibitor 1466 (CAM-I 1466)

生物&药学活性

物理化学性质&存储条件

参考文献

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