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首页-小分子抑制剂&激动剂-Others-Midkine-HBS-101
HBS-101

Chemical Structure : HBS-101

CAS No.:

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HBS-101 (HBS101)

货号: PC-24528Not For Human Use, Lab Use Only.

HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.
HBS-101 exhibits distinct pharmacologic advantages, including oral bioavailability, blood-brain-barrier penetration, and in vivo stability.
The underlying mechanism of HBS-101 involves suppression of Akt/mTOR, STAT3, and NF-B pathways.
HBS-101 inhibits growth of TNBC patient-derived xenograft tumors in vivo and markedly reduced TNBC brain-metastatic-tumor growth and prolonged mice survival.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Mahajan M, et al. Mol Cancer Ther. 2025 Apr 30. doi: 10.1158/1535-7163.MCT-25-0130.

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