HB007 | SUMO1 degrader | Probechem Biochemicals

Chemical Structure : HB007

CAS No.: 2387821-46-5

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HB007 (HB 007, HB-007)

货号: PC-72801Not For Human Use, Lab Use Only.

HB007 (HB-007) is a small-molecule degrader of the small ubiquitin-related modifier 1 (SUMO1) with anticancer potency in vitro and in vivo.

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10 mg	￥3780	In stock
25 mg	￥5780	In stock
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生物&药学活性

HB007 (HB-007) is a small-molecule degrader of the small ubiquitin-related modifier 1 (SUMO1) with anticancer potency in vitro and in vivo.
HB007 selectively bound to cytoplasmic activation/proliferation-associated protein 1 (CAPRIN1), induced the interaction of CAPRIN1 with FBXO42, FBXO42 then recruited SUMO1 to the CAPRIN1-CUL1-FBXO42 ubiquitin ligase complex, where SUMO1 was ubiquitinated in several of human cancer cells.
HB007 selectively degraded SUMO1 in patient tumor-derived xenografts implanted into mice.
Systemic administration of HB007 inhibited the progression of patient-derived brain, breast, colon, and lung cancers in mice and increased survival of the animals.

物理化学性质&存储条件

分子量	328.78
分子式	C15H9ClN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-

参考文献

1. Anita C Bellail, et al. Sci Transl Med. 2021 Oct 13;13(615):eabh1486.

HB007 (HB 007, HB-007)

生物&药学活性

物理化学性质&存储条件

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HB007 (HB 007, HB-007)

生物&药学活性

物理化学性质&存储条件

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