HAMNO | RPA inhibitor | Probechem Biochemicals

Chemical Structure : HAMNO

CAS No.: 138736-73-9

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HAMNO (NSC 111847)

货号: PC-21246Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

HAMNO (NSC 111847) is a small molecule protein interaction inhibitor of replication protein A (RPA), specifically inhibits RPA DNA binding domain F (DBD-F), inhibits dsDNA unwinding with IC50 of 9 uM.
HAMNO (NSC 111847) is selective for inhibiting only DBD-F, but not DBDs A-E which are important in RPA binding to ssDNA.
HAMNO (NSC 111847) selectively binds the N-terminal domain of RPA70, effectively inhibiting critical RPA protein interactions.
HAMNO (NSC 111847) induces γ-H2AX staining in a cell-cycle specific manner, alters RPA32 and ATR phosphorylation.
HAMNO (NSC 111847) inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR.
HAMNO (NSC 111847) enhances etoposide toxicity, HAMNO (NSC 111847) (1mg/kg) slowed the progression of UMSCC11B tumors in mouse xenograft model.

物理化学性质&存储条件

分子量	263.30
分子式	C17H13NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1Z)-1-[(2-hydroxyanilino)methylidene]naphthalen-2-one

参考文献

1. Glanzer JG, et al. Cancer Res. 2014 Sep 15;74(18):5165-72.

2. Glanzer JG, et al. Bioorganic & medicinal chemistry. 2011;19:2589–95.

HAMNO (NSC 111847)

生物&药学活性

物理化学性质&存储条件

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HAMNO (NSC 111847)

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