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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Autotaxin-HA130
HA130

Chemical Structure : HA130

CAS No.: 1229652-21-4

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HA130 (HA-130;HA 130)

货号: PC-45610Not For Human Use, Lab Use Only.

HA130 (HA-130) is a potent and selective inhibitor of autotaxin with IC50 of 28 nM.

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10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HA130 (HA-130) is a potent and selective inhibitor of autotaxin with IC50 of 28 nM.
HA130 shows no effect on chymotryptic, caspase, and tryptic activities of the proteasome, alkaline phosphatase and a broad-spectrum PEDs (IC50>10 uM)。
HA130 inhibits ATX-driven melanoma cell migration and decreases circulating LPA levels in mice.

物理化学性质&存储条件

分子量 463.2858
分子式 C24H19BFNO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 39 mg/mL
Chemical Name/SMILES

Boronic acid, B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-

参考文献

1. Albers HM, et al. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7257-62.

2. Zhang Y, et al. J Immunol. 2012 Oct 15;189(8):3914-24.

3. Lai SL, et al. Development. 2012 Dec 1;139(23):4439-48.

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