HA-15 |CAS:1609402-14-3 Probechem Biochemicals

Chemical Structure : HA-15

CAS No.: 1609402-14-3

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HA-15 (HA15;HA 15)

货号: PC-42156Not For Human Use, Lab Use Only.

HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells.

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25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4980	In stock
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1 g		Get quote

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生物&药学活性

HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells.
HA-15 does not interact with IRE1α, ATF6, or HSP70, increases ER stress and induces autophagy and apoptosis.
HA-15 exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitor.

物理化学性质&存储条件

分子量	466.5758
分子式	C23H22N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-

参考文献

1. Cerezo M, et al. Cancer Cell. 2016 Jun 13;29(6):805-819.

HA-15 (HA15;HA 15)

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物理化学性质&存储条件

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HA-15 (HA15;HA 15)

生物&药学活性

物理化学性质&存储条件

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