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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -H3B-968
H3B-968

Chemical Structure : H3B-968

CAS No.: 2912294-90-5

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H3B-968 (H3B 968)

货号: PC-21006Not For Human Use, Lab Use Only.

H3B-968 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 41 and 13 nM in ADP-Glo assay DNA unwinding assay, respectively.

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10 mg ￥4580 In stock
25 mg ￥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

H3B-968 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 41 and 13 nM in ADP-Glo assay DNA unwinding assay, respectively.

物理化学性质&存储条件

分子量 548.46
分子式 C22H18F6N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-ethylphenyl)-2-((4-(4-(trifluoromethoxy)phenyl)-6-(trifluoromethyl)pyrimidine)-2-sulfonamido)acetamide

参考文献

1. Mackenzie J Parker, et al. Biochemistry. 2023 Jul 18;62(14):2147-2160.

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