H3B-6527 |CAS:1702259-66-2 Probechem Biochemicals

Chemical Structure : H3B-6527

CAS No.: 1702259-66-2

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H3B-6527 (H3B 6527;H3B6527)

货号: PC-60784Not For Human Use, Lab Use Only.

H3B-6527 is a potent, highly selective covalent FGFR4 inhibitor with IC50 of <1.2 nM, 250-fold selectivity over FGFR1-3 (IC50=320, 1290 and 1060 nM, respectively).

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10 mg	￥2680	In stock
25 mg	￥4580	In stock
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生物&药学活性

H3B-6527 is a potent, highly selective covalent FGFR4 inhibitor with IC50 of <1.2 nM, 250-fold selectivity over FGFR1-3 (IC50=320, 1290 and 1060 nM, respectively).
H3B-6527 displays liitle to no inhibitory activity against TAOK2, JNK2 and CSF1R (IC50=690, >10,000, and >10,000 nM).
H3B-6527 inhibits Hep3B celll viability with GI50 of 25 nM in ATP-based cell viability assay, inhibits proliferation and leads to apoptosis in HCC cell lines by inhibiting FGFR4 signaling.
H3B-6527 exhibits antitumor activity in the Hep3B human HCC xenograft mouse model.

物理化学性质&存储条件

分子量	629.543
分子式	C29H34Cl2N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[[6-[[[(2,6-Dichloro-3,5-dimethoxyphenyl)amino]carbonyl]methylamino]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)phenyl]-2-propenamide

参考文献

1. Joshi JJ, et al. Cancer Res. 2017 Dec 15;77(24):6999-7013.

H3B-6527 (H3B 6527;H3B6527)

生物&药学活性

物理化学性质&存储条件

参考文献

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H3B-6527 (H3B 6527;H3B6527)

生物&药学活性

物理化学性质&存储条件

参考文献

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