H3B-5942 |CAS:2052128-15-9 Probechem Biochemicals

Chemical Structure : H3B-5942

CAS No.: 2052128-15-9

加入收藏

H3B-5942 (H3B5942)

货号: PC-35365Not For Human Use, Lab Use Only.

H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA) with Ki 1 nM and 0.41 nM for wild-type and mutant ERα Y537S respectively, covalently targeting Cys530.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA) with Ki 1 nM and 0.41 nM for wild-type and mutant ERα Y537S respectively, covalently targeting Cys530.
H3B-5942 demonstrates potent ERα antagonist activity in vitro and in vivo.
H3B-5942 covalently inactivates both wild-type and mutant ERα by targeting Cys530 and enforcing a unique antagonist conformation.
H3B-5942 demonstrates significant single-agent antitumor activity in xenograft models representing ERαWT and ERα Y537S breast cancer, which is superior to fulvestrant (Cat# PC-21622).

物理化学性质&存储条件

分子量	494.639
分子式	C31H34N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((2-(4-((E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)amino)-N,N-dimethylbut-2-enamide

参考文献

1. Puyang X, et al. Cancer Discov. 2018 Jul 10. pii: CD-17-1229.

H3B-5942 (H3B5942)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

H3B-5942 (H3B5942)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.