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首页-小分子抑制剂&激动剂-Others-Other Targets-H3B-120
H3B-120

Chemical Structure : H3B-120

CAS No.: 2194903-42-7

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H3B-120 (H3B 120)

货号: PC-38214Not For Human Use, Lab Use Only.

H3B-120 (H3B 120) is a selective allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with Ki of 1.4 uM, does not bind to CPS2.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

H3B-120 (H3B 120) is a selective allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with Ki of 1.4 uM, does not bind to CPS2。
H3B-120 demonstrated complete inhibition of both ATP activity and carbamoyl phosphate synthetase activity of CPS1 with IC50 of 1.5 uM.
H3B-120 blocks pyrimidine labeling in hepatocytes treated with 15N-ammonia, inhibits urea production in a dose-dependent manner, although the cellular potency decreased significantly compared with enzymatic assays.

物理化学性质&存储条件

分子量 372.487
分子式 C19H24N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide

参考文献

1. Yao S, et al. Cell Chem Biol. 2020 Mar 19;27(3):259-268.e5.

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