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首页-抗体和重组蛋白-Biosimilar Antibody-Guselkumab
Guselkumab

Chemical Structure : Guselkumab

CAS No.: 1350289-85-8

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Guselkumab (Anti-human IL23 mAb, human IgG1-Lambda3; CNTO-1959)

货号: PC-Ab1109Not For Human Use, Lab Use Only.

Guselkumab (CNTO-1959) is a fully human immunoglobulin-G1-lambda (IgG1λ) monoclonal antibody, selectively binds to the p19 subunit of IL-23 in dendritic cells and keratinocytes and blocks its interaction with the IL-23 receptor, which further prevents the release of other pro-inflammatory cytokines and chemokines via stimulation of immune cells, such as T helper 17 (Th17) cells. Guselkumab serum levels of IL-17A, IL-17F, and IL-22, inhibits the release of proinflammatory cytokines and chemokines

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Guselkumab (CNTO-1959) is a fully human immunoglobulin-G1-lambda (IgG1λ) monoclonal antibody, selectively binds to the p19 subunit of IL-23 in dendritic cells and keratinocytes and blocks its interaction with the IL-23 receptor, which further prevents the release of other pro-inflammatory cytokines and chemokines via stimulation of immune cells, such as T helper 17 (Th17) cells. Guselkumab serum levels of IL-17A, IL-17F, and IL-22, inhibits the release of proinflammatory cytokines and chemokines.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Lambda3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Guselkumab; CNTO-1959; CNTO1959; Tremfya; 1350289-85-8; Anti human IL23; Anti human interleukin 23

参考文献

1. 1, Sofen H, et al. J Allergy Clin Immunol. 2014 Apr;133(4):1032-40. 2, Gordon KB, et al. N Engl J Med. 2015 Jul 9;373(2):136-44. 3, Bilal J, et al. J Dermatolog Treat. 2018 Sep;29(6):569-578.

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