ICP-192 (Gunagratinib) | FGFR inhibitor | Probechem Biochemicals

Chemical Structure : Gunagratinib

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Gunagratinib (ICP-192, ICP192, ICP-CL-00301)

货号: PC-38396Not For Human Use, Lab Use Only.

ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding.

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生物&药学活性

ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding.
ICP-192 (Gunagratinib) overcomes the acquired resistance to the first-generation reversible FGFR inhibitors, e.g., infigratinib.

物理化学性质&存储条件

分子量	423.473
分子式	C22H25N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide

参考文献

1. Ye Guo, et al. 2021 ASCO Annual Meeting I.

Gunagratinib (ICP-192, ICP192, ICP-CL-00301)

生物&药学活性

物理化学性质&存储条件

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Gunagratinib (ICP-192, ICP192, ICP-CL-00301)

生物&药学活性

物理化学性质&存储条件

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