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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-Guanabenz acetate
Guanabenz acetate

Chemical Structure : Guanabenz acetate

CAS No.: 23256-50-0

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Guanabenz acetate (Wytensin, WY-8678 acetate)

货号: PC-35504Not For Human Use, Lab Use Only.

Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α.
Guanabenz acetate prolongs eIF2α phosphorylation in human stressed cells, without affecting the related PPP1R15B-phosphatase complex and constitutive protein synthesis.
Guanabenz acetate accelerates ALS-like disease progression in a strain of mutant SOD1 transgenic ALS mice.
Guanabenz acetate exhibits anti-inflammatory activity by increasing in vitro IL-10 production by LPS-stimulated dendritic cells, prevents d-Galactosamine/LPS-induced liver damage and mortality in vivo.

物理化学性质&存储条件

分子量 291.132
分子式 C10H12Cl2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, monoacetate (9CI)

参考文献

1. Carrara M, et al. Nat Struct Mol Biol. 2017 Sep;24(9):708-716.

2. Tsaytler P, et al. Science. 2011 Apr 1;332(6025):91-4.

3. Vieira FG, et al. PLoS One. 2015 Aug 19;10(8):e0135570.

4. Perego J, et al. Front Immunol. 2017 Jun 13;8:679.

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