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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-Guanabenz
Guanabenz

Chemical Structure : Guanabenz

CAS No.: 5051-62-7

Guanabenz (WY 8678)

货号: PC-62319Not For Human Use, Lab Use Only.

Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.
Guanabenz also has antiparasitic activity against replicative stages of Toxoplasma.

物理化学性质&存储条件

分子量 231.08
分子式 C8H8Cl2N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine

参考文献

1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42.

2. Crespillo-Casado A, et al. Elife. 2017 Apr 27;6. pii: e26109.

3. Benmerzouga I, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):6939-45.

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