Chemical Structure : GsMTx4
CAS No.: 1209500-46-8
货号: PC-20552Not For Human Use, Lab Use Only.
GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
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---|---|---|---|
0.5 mg | ¥2280 | In stock | |
1 mg | ¥3580 | In stock | |
2 mg | ¥5480 | In stock | |
5 mg | Get quote | ||
10 mg | Get quote |
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GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
GsMTx4 attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity.
GsMTx4 (5 μM) reduces Piezo1-mediated charge transfer to 38% of its initial levels in HEK293 cells transfected with Piezo1 cDNA.
GsMTx4 (5 μM) blocks cation-selective stretch-activated channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response.
GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice.
分子量 | 4095.86 | |
分子式 | C185H273N49O45S6 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Sequence: GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30) |
1. Suchyna TM, et al. Nature. 2004 Jul 8;430(6996):235-40.
2. Suchyna TM, et al. J Gen Physiol. 2000 May;115(5):583-98.
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