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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-GsMTx4
GsMTx4

Chemical Structure : GsMTx4

CAS No.: 1209500-46-8

GsMTx4

货号: PC-20552Not For Human Use, Lab Use Only.

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
GsMTx4 attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity.
GsMTx4 (5 μM) reduces Piezo1-mediated charge transfer to 38% of its initial levels in HEK293 cells transfected with Piezo1 cDNA.
GsMTx4 (5 μM) blocks cation-selective stretch-activated channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response.
GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice.

物理化学性质&存储条件

分子量 4095.86
分子式 C185H273N49O45S6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Sequence: GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30)

参考文献

1. Suchyna TM, et al. Nature. 2004 Jul 8;430(6996):235-40.

2. Suchyna TM, et al. J Gen Physiol. 2000 May;115(5):583-98.

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