Grp78 inhibitor 8

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-Grp78 inhibitor 8

Chemical Structure : Grp78 inhibitor 8

CAS No.: 2707510-30-1

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货号: PC-49601Not For Human Use, Lab Use Only.

Grp78 inhibitor 8 is a potent, isoform-selective inhibitor of the ER Resident Chaperone Grp78 (HSPA5) with IC50 of 0.59 uM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Grp78 inhibitor 8 is a potent, isoform-selective inhibitor of the ER Resident Chaperone Grp78 (HSPA5) with IC50 of 0.59 uM.
Grp78 inhibitor 8 is 7-fold selective for HspA5 over HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM).

物理化学性质&存储条件

分子量	342.42
分子式	C17H18N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)-1H-indole-2-carboxamide

参考文献

1. Ambrose AJ,et al. J Med Chem. 2022 Dec 14. doi: 10.1021/acs.jmedchem.2c01631.

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