Gosogliptin |CAS:869490-23-3 Probechem Biochemicals

Chemical Structure : Gosogliptin

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Gosogliptin (PF-734200;PF 734200;PF734200;PF 00734200)

货号: PC-60516Not For Human Use, Lab Use Only.

Gosogliptin (PF-734200, PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.

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生物&药学活性

Gosogliptin (PF-734200, PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
Gosogliptin demonstrates >200-fold selectivity over other members of the DPP family (DPP-2, DPP-3, DPP-8, and DPP-9) and the related serine proteases, FAP, aminopeptidase P, and propyl oligopeptidase.
Gosogliptin shows potential treatment for type 2 diabetes.

物理化学性质&存储条件

分子量	366.417
分子式	C17H24F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone

参考文献

1. Ammirati MJ, et al. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5.

2. Dai H, et al. Br J Clin Pharmacol. 2011 Jul;72(1):85-91.

3. Sharma R, et al. Drug Metab Dispos. 2012 Nov;40(11):2143-61.

4. Rosenstock J, et al. Diabet Med. 2011 Apr;28(4):464-9.

Gosogliptin (PF-734200;PF 734200;PF734200;PF 00734200)

生物&药学活性

物理化学性质&存储条件

参考文献

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Gosogliptin (PF-734200;PF 734200;PF734200;PF 00734200)

生物&药学活性

物理化学性质&存储条件

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