Golgicide A |CAS:1139889-93-2 Probechem Biochemicals

Chemical Structure : Golgicide A

CAS No.: 1139889-93-2

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Golgicide A

货号: PC-62234Not For Human Use, Lab Use Only.

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM.

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25 mg	￥1880	In stock
50 mg	￥2880	In stock
100 mg	￥4580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM.
Golgicide A causes complete dispersal of the medial-Golgi markers giantin and the cis-Golgi marker GM130
Golgicide A causes a decrease in GBF1-mediated Arf1 activation; inhibits swine vesicular disease virus (SVDV) procution.

物理化学性质&存储条件

分子量	284.31
分子式	C17H14F2N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,9bS)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

参考文献

1. Sáenz JB, et al. Nat Chem Biol. 2009 Mar;5(3):157-65.

2. Ignashkova TI, et al. Traffic. 2017 Aug;18(8):530-544.

3. Vázquez-Calvo Á, et al. Front Microbiol. 2016 Apr 27;7:612.

Golgicide A

生物&药学活性

物理化学性质&存储条件

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Golgicide A

生物&药学活性

物理化学性质&存储条件

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