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首页-抗体和重组蛋白-Other Fusion Proteins-Goflikicept
Goflikicept

Chemical Structure : Goflikicept

CAS No.: 2416984-26-2

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Goflikicept (RPH-104)

货号: PC-38883Not For Human Use, Lab Use Only.

Goflikicept (RPH-104) is a heterodimeric fusion protein containing IL-1R1 and IL-1RAcP linked to immunoglobulin heavy chains and is highly selectively binds IL-1B, affecting IL-1B signalling pathways, inhibits widespread inflammation.

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    生物&药学活性

    Goflikicept (RPH-104) is a heterodimeric fusion protein containing IL-1R1 and IL-1RAcP linked to immunoglobulin heavy chains and is highly selectively binds IL-1B, affecting IL-1B signalling pathways, inhibits widespread inflammation.
    Human interleukin-1 receptor accessory protein fragment (21-358, 1-338 in the current sequence) fused via peptidyl linker 339GSGGG343 to a human immunoglobulin G1 Fc fragment (344-570, C-terminal Lys clipped) variant (S>C477, T>W489, K>A532), covalent dimer with human interleukin-1 receptor type 1 fragment (21-333, 1-313 in the current sequence) fused via peptidyl linker 314GSGG318 to a human immunoglobulin G1 Fc fragment (319-545, C-terminal Lys clipped) variant (Y>C447, T>S464, L>A466, F>K503, Y>V505), glycosylated, produced in Chinese hamster ovary (CHO) cells.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    Chemical Name/SMILES

    Goflikicept

    参考文献

    1. Samsonov M, et al. J Transl Med. 2021 Apr 26;19(1):169.

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